Invariably - log in to cPanel and find the Autoresponders icon, then add the autoresponder
Fill in the fields according to your needs and of course don't forget to add an autoresponder.
See also
What do i need to set up an e-mail account?
How to set up an e-mail account in cPanel?
Can I use e-mail via my browser?
Can I use my e-mail via an e-mail client such as Thunderbird, Outlook?
Are there any size limits for attachments?
What are the limits for sending mail?
How many recipients can I send an e-mail at once?
Can I limit the space for an e-mail account?
What to do when e-mail does not work (not arriving, not sending messages)?
What to do when individual messages do not arrive in the inbox?
What to do when individual messages are not being sent and I am receiving Mailer-Daemon returns?
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